Danazol decreases transcription of estrogen receptor gene in human monocytes.

J Fujimoto, M Hori, T Itoh, S Ichigo, M Nishigaki, T Tamaya

Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.

General pharmacology 1995 May

filter terms:

1. Administration of danazol for over one month reduced the levels of estrogen receptor (ER) and its mRNA to approximately 50 and 20%, respectively in monocytes. 2. Danazol did not alter the degradation rate of ER mRNA in monocytes. 3. Danazol decreased the transcription rate of ER gene to approximately 50% in monocytes in a run-on assay. 4. Danazol may release estrogen predominance via the reduction of transcription for ER gene, which leads to the reduction of ER mRNA and ER expressions in monocytes.

Citation

J Fujimoto, M Hori, T Itoh, S Ichigo, M Nishigaki, T Tamaya. Danazol decreases transcription of estrogen receptor gene in human monocytes. General pharmacology. 1995 May;26(3):507-16