Intimate relationships of the large and the small subunits of all nickel hydrogenases with two nuclear-encoded subunits of mitochondrial NADH: ubiquinone oxidoreductase.

S P Albracht

E.C. Slater Institute, BioCentrum, University of Amsterdam, The Netherlands.

Biochimica et biophysica acta 1993 Sep 13

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The sequence pattern CxxCxnGxCxxxGxmGCPP, thus far found in the small subunits from 21 different nickel hydrogenases, appears also to be present in the PSST polypeptide from NADH:ubiquinone oxidoreductase (Complex I) of beef-heart mitochondria. There is only one difference: the first cysteine residue is a leucine in the PSST subunit. The large nickel-binding subunit of nickel hydrogenases shows a surprising homology with the 49 kDa subunit of mitochondrial Complex I.

Citation

S P Albracht. Intimate relationships of the large and the small subunits of all nickel hydrogenases with two nuclear-encoded subunits of mitochondrial NADH: ubiquinone oxidoreductase. Biochimica et biophysica acta. 1993 Sep 13;1144(2):221-4