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Cimetidine therapy used for the treatment of gastric bleeding due to tolazoline therapy in a newborn infant was temporally associated with episodes of severe hypoxemia. It appears likely that the histamine H2 receptor blocked by cimetidine obviated the pulmonary vasodilator effect of tolazoline therapy.

Citation

J Kuint, N Linder, B Reichman. Hypoxemia associated with cimetidine therapy in a newborn infant. American journal of perinatology. 1996 Jul;13(5):301-3

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PMID: 8863950

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