The anti-inflammatory effects of ketoprofen in animal experiments.

L M Wang, A Toyoshima, S Mineshita, X X Wang, T Yamamoto, Y Nomura, L Yang, Y Koikei, K Shiba, Y Honda

Department of Preventive Medicine, Tokyo Medical and Dental University, Japan.

Drugs under experimental and clinical research 1997

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The authors investigated the anti-inflammatory actions of ketoprofen using a battery of tests: in the rat paw oedema test induced by five different inciters, in the capillary permeability test, and in measuring the interleukin-8 (IL-8) production and superoxide dismutase (SOD) activity. The findings in these studies show that ketoprofen inhibits rat paw oedema, suppresses capillary permeability, reduces IL-8 production and increases SOD activity in the acetic-acid-induced inflammatory state. These results would seem to provide a clear rationale for exploring the usefulness of ketoprofen in the treatment of acute and chronic inflammatory diseases.

Citation

L M Wang, A Toyoshima, S Mineshita, X X Wang, T Yamamoto, Y Nomura, L Yang, Y Koikei, K Shiba, Y Honda. The anti-inflammatory effects of ketoprofen in animal experiments. Drugs under experimental and clinical research. 1997;23(1):1-6