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Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts.
C Guillou, A Mary, D Z Renko, E Gras, C Thal
Institut de Chimie des Substances Naturelles, C.N.R.S., Gif-sur-Yvette, France. guillou@icsn.cnrs-gif.fr
Bioorganic & medicinal chemistry letters 2000 Apr 3Sizes of these terms reflect their relevance to your search.
The syntheses, the anticholinesterase activities and structure-activity relationships of homodimeric (3a-c) and heterodimeric (6a-c) alkylene linked bis-galanthamine are reported. Compounds 6b-c were found to be more potent than galanthamine and tacrine in inhibiting AChE.
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C Guillou, A Mary, D Z Renko, E Gras, C Thal. Potent acetylcholinesterase inhibitors: design, synthesis and structure-activity relationships of alkylene linked bis-galanthamine and galanthamine-galanthaminium salts. Bioorganic & medicinal chemistry letters. 2000 Apr 3;10(7):637-9
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PMID: 10762042
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