Robin E Pearce, J Steven Leeder, Gregory L Kearns
Division of Pediatric Clinical Pharmacology and Medical Toxicology, Department of Pediatrics, Children's Mercy Hospitals and Clinics, Kansas City, MO 64108, USA.
Drug metabolism and disposition: the biological fate of chemicals 2006 JunFluticasone propionate (FTP) is a synthetic trifluorinated glucocorticoid with potent anti-inflammatory action that is commonly used in patients with asthma. After oral or intranasal administration, FTP undergoes rapid hepatic biotransformation; the principal metabolite formed is a 17beta-carboxylic acid derivative (M1). M1 formation has been attributed largely to cytochrome P450 3A4 (CYP3A4); however, there are no published data that confirm this assertion. Hence, in vitro studies were conducted to determine the role that human P450s play in the metabolism of FTP. Consistent with in vivo data, human liver microsomes catalyzed the formation of a single metabolite (M1) at substrate concentrations
Robin E Pearce, J Steven Leeder, Gregory L Kearns. Biotransformation of fluticasone: in vitro characterization. Drug metabolism and disposition: the biological fate of chemicals. 2006 Jun;34(6):1035-40
PMID: 16565171
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