Correlation Engine 2.0
Clear Search sequence regions

Inhibitors of xanthine oxidoreductase decrease production of uric acid, thus they act as hypouricemic drugs. Allopurinol, a prototypical xanthine oxidoreductase inhibitor, has been widely prescribed for treatment of gout and hyperuricemia. However, severe side effects of allopurinol may occur in patients with renal insufficiency. Recently, novel nonpurine selective inhibitors of xanthine oxidoreductase have been developed as potential alternatives to allopurinol. They have different inhibition mechanisms, utilizing the enzyme structure and the reaction mechanism. Such variation of the inhibition mechanism affects/in vivo/hypouricemic effects of the inhibitors.


Ken Okamoto. Inhibitors of xanthine oxidoreductase]. Nihon rinsho. Japanese journal of clinical medicine. 2008 Apr;66(4):748-53

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 18409526

View Full Text