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Recent advances in understanding how actinomycin binds to DNA have suggested its mechanism of action. Actinomycin binds to a premelted DNA conformation present within the transcriptional complex. This immobilizes the complex, interfering with the elongation of growing RNA chains. The model has a number of implications for understanding RNA synthesis.


H M Sobell. Actinomycin and DNA transcription. Proceedings of the National Academy of Sciences of the United States of America. 1985 Aug;82(16):5328-31

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PMID: 2410919

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