Glaxo Wellcome, Stockley Park West, Uxbridge, Middlesex, England.
Cutis 1996 FebFluticasone propionate is a potent fluorinated corticosteroid used for the topical therapy of dermatoses and as inhalation therapy for bronchial asthma and allergic rhinitis. This agent has a good safety profile with a low propensity for systemic side effects, such as suppression of the hypothalamic-pituitary-adrenal (HPA) axis, and a low incidence of local side effects such as pruritus, burning, or skin atrophy. The pharmacologic properties of fluticasone propionate-including high lipophilicity, high selectivity and affinity for the glucocorticoid receptor, low systemic absorption, and rapid metabolism and clearance-combine to give fluticasone propionate a high therapeutic index.
M Johnson. Fluticasone propionate: safety profile. Cutis. 1996 Feb;57(2 Suppl):10-2
PMID: 8646863
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