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In this work, we evaluated the effects of allopurinol (ALO), an inhibitor of xanthine oxidase (XO), on hepatic lesions caused by ischemia/reperfusion (I/R) in the rabbit liver. Rabbits were pretreated with ALO (10 mg/kg IV) or saline solution 0.9% before the hepatic I/R procedure. The effects of ALO on hepatic injury were evaluated before and after I/R. A standard, warm hepatic I/R procedure caused profound acute liver injury, as indicated by elevated serum aspartate aminotransferase, alanine aminotransferase, and lactic dehydrogenase levels, as well as a high apoptotic cell count. All of these changes were reversed by the administration of ALO before the hepatic I/R procedure. In conclusion, ALO exerted protective effects on hepatic I/R lesions. This protective effect of ALO was probably associated with blocking the generation of superoxide anions during the hepatic I/R procedure by inhibiting XO activity.


M O Taha, M J Simões, E C Noguerol, F P Mendonça, H M A Pascoalick, R A M Alves, M E M Vivian, F P Morales, A C A Campos, K G Magalhães, P S Venerando, I L S Tersariol, H P Monteiro, I S Oliveira-Júnior, I Oliveira, A Jurkiewicz, A Caricati-Neto. Effects of allopurinol on ischemia and reperfusion in rabbit livers. Transplantation proceedings. 2009 Apr;41(3):820-3

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PMID: 19376361

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