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Supernatant protein factor (SPF) and alpha-tocopherol-associated protein (TAP) both belong to a widespread lipid-binding Sec 14-like protein family. All the members of the family have the lipid-binding motif called CRAL_TRIO. SPF is showed to stimulate the conversion of squalene to lanosterol and enhance cholesterol biosynthesis. TAP is identified to be involved in the intracellular distribution of alpha-tocopherol. Recently TAP is identified as SPF though they have very different functions. Here we report a human SPF/TAP homology SEC14L3 with 2082 base pairs in length and contains an open reading frame encoding a 400 amino acids protein. Analysis shows that SEC14L3 is mapped to 22q12 and expresses only in the liver among the used sixteen tissues in the test.


Xin Ye, Chaoneng Ji, Gang Yin, Rong Tang, Li Zeng, Shaohua Gu, Kang Ying, Yi Xie, Robert Chunhua Zhao, Yumin Mao. Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. Molecular biology reports. 2004 Mar;31(1):59-63

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PMID: 15040456

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