Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride.

L Schjelderup, M R Kozlowski, A Weissman, A J Aasen

Department of Chemistry, Agricultural University of Norway.

Pharmaceutical research 1988 Apr

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The (R)-(+)- and (S)-(-)-enantiomers of the anticholinergic compound, oxyphencyclimine, were synthesized from (R)-(-)- and (S)-(+)-2-cyclohexyl-2-hydroxy-2-phenylethanoic acid, respectively. The potencies of the enantiomers were compared using a cholinergic receptor binding assay. The (R)-(+)-enantiomer inhibited binding 29 times more potently than the (S)-(-)-enantiomer.

Citation

L Schjelderup, M R Kozlowski, A Weissman, A J Aasen. Antimuscarinic effects of (R)- and (S)- oxyphencyclimine hydrochloride. Pharmaceutical research. 1988 Apr;5(4):236-7