Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms.

There has been a renewed interest in using polymyxin B as a last resort therapeutic option, due to emergence of multidrug-resistant Gram-negative bacteria. Despite being available for clinical use for decades, there is still a very limited understanding on many aspects of this agent. To review what is known about polymyxin B and to identify missing information or gaps for future investigations. Pertinent information was reviewed from published literature in English. For optimal use of polymyxin B, a more thorough understanding is needed on standardized susceptibility testing, serum and tissue concentrations achieved, antibacterial activity when polymyxin B is combined with other agents, and mechanisms of resistance. A more precise characterization of the relationship between drug concentration and toxicity is also required.

Citation

Zhe Yuan, Vincent H Tam. Polymyxin B: a new strategy for multidrug-resistant Gram-negative organisms. Expert opinion on investigational drugs. 2008 May;17(5):661-8

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PMID: 18447592

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