Identification and characterization of a prostaglandin transporter.

N Kanai, R Lu, J A Satriano, Y Bao, A W Wolkoff, V L Schuster

Science (New York, N.Y.) 1995 May 12

filter terms:

Carrier-mediated prostaglandin transport has been postulated to occur in many tissues. On the basis of sequence homology, the protein of unknown function encoded by the rat matrin F/G complementary DNA was predicted to be an organic anion transporter. Expression of the matrin F/G complementary DNA in HeLa cells or Xenopus oocytes conferred the property of specific transport of prostaglandins. The tissue distribution of matrin F/G messenger RNA and the sensitivity of matrin F/G-induced prostaglandin transport to inhibitors were similar to those of endogenous prostaglandin transport. The protein encoded by the matrin F/G complementary DNA is thus preferably called PGT because it is likely to function as a prostaglandin transporter.

Citation

N Kanai, R Lu, J A Satriano, Y Bao, A W Wolkoff, V L Schuster. Identification and characterization of a prostaglandin transporter. Science (New York, N.Y.). 1995 May 12;268(5212):866-9