Correlation Engine 2.0
Clear Search sequence regions

The advanced macrolides, azithromycin and clarithromycin, and the ketolide, telithromycin, are structural analogs of erythromycin. They have several distinct advantages when compared with erythromycin, including enhanced spectrum of activity, more favorable pharmacokinetics and pharmacodynamics, once-daily administration, and improved tolerability. Clarithromycin and azithromycin are used extensively for the treatment of respiratory tract infections, sexually transmitted diseases, and Helicobacter pylori-associated peptic ulcer disease. Telithromycin is approved for the treatment of community-acquired pneumonia. Severe hepatotoxicity has been reported with the use of telithromycin.


Jerry M Zuckerman, Fozia Qamar, Bartholomew R Bono. Macrolides, ketolides, and glycylcyclines: azithromycin, clarithromycin, telithromycin, tigecycline. Infectious disease clinics of North America. 2009 Dec;23(4):997-1026, ix-x

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 19909895

View Full Text