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The effect of diuretics on tryptophan fluorescence of blood serum proteins divided by electrophoresis was studied. It was shown that ethacrynic acid produces the most significant extinction of tryptophan fluorescence in albumin fraction and novurit in globulin fraction. Furosemide possessing a high affinity for all three obtained fractions of protein does not exhibit a preferential binding to one or another of these fractions. It was also found that furosemide and ethacrynic acid by binding to human serum albumin molecule produce its conformational alterations. Mercury diuretic does not possess such effect.


A A Lebedev, O V Samokrutova. Study of the binding of diuretics by serum proteins according to changes in tryptophan fluorescence]. Farmakologiia i toksikologiia. 1989 May-Jun;52(3):40-3

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PMID: 2792351

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