Altered membrane permeability as the basis of bactericidal action of methdilazine.

The growth inhibition of Escherichia coli and Staphylococcus aureus was accompanied by significant release of K+ and UV-absorbing small molecules upon exposure to methdilazine, an extensively used phenothiazine antihistamine. A severe decrease in [U-14C] glucose uptake and a rapid efflux of hexose from sugar-preloaded bacteria were also observed but without visible cellular lysis. Considerable damage to membrane permeability by methdilazine was proposed to explain the rapid loss in cfu/mL of the bacteria.

Citation

D Chattopadhyay, T Mukherjee, P Pal, B Saha, R Bhadra. Altered membrane permeability as the basis of bactericidal action of methdilazine. The Journal of antimicrobial chemotherapy. 1998 Jul;42(1):83-6

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PMID: 9700532

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