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Substituted heterocyclic analogs in the Flosulide class were investigated as potential selective cyclooxygenase-2 inhibitors. 6-(4-Ethyl-2-thiazolylthio)-5-methanesulfonamido-3H-isobe nzofuran-1-one 14 was found to be the optimal compound in the series with superior in vitro and in vivo activities.


N Ouimet, C C Chan, S Charleson, D Claveau, R Gordon, D Guay, C S Li, M Ouellet, D M Percival, D Riendeau, E Wong, R Zamboni, P Prasit. Substituted heterocyclic analogs as selective COX-2 inhibitors in the flosulide class. Bioorganic & medicinal chemistry letters. 1999 Jan 18;9(2):151-6

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PMID: 10021918

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