Expression of atrC - encoding a novel member of the ATP binding cassette transporter family in Aspergillus nidulans - is sensitive to cycloheximide.

K Angermayr, W Parson, G Stöffler, H Haas

Department of Microbiology, University of Innsbruck, Medical School, Fritz-Pregl-Str. 3, A-6020, Innsbruck, Austria. klaus.angermayr@uibk.ac.at

Biochimica et biophysica acta 1999 Feb 24

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A new member of the ABC superfamily of transmembrane proteins in Aspergillus nidulans has been cloned and characterized. The topology of conserved motifs subgroups AtrC in the P-glycoprotein cluster of ABC permeases, the members of this subfamily, are known to participate in multidrug resistance (MDR) in diverse organisms. Alignment results display significant amino acid similarity to AfuMDR1 and AflMDR1 from Aspergillus fumigatus and flavus, respectively. Northern analysis reveals that atrC mRNA levels are 10-fold increased in response to cycloheximide. Evidence for the existence of eight additional hitherto unpublished ABC transporter proteins in A. nidulans is provided.

Citation

K Angermayr, W Parson, G Stöffler, H Haas. Expression of atrC - encoding a novel member of the ATP binding cassette transporter family in Aspergillus nidulans - is sensitive to cycloheximide. Biochimica et biophysica acta. 1999 Feb 24;1453(2):304-10