Protection against endothelial abnormalities by a novel calcium channel blocker, AE0047, in stroke-prone spontaneously hypertensive rats.

M Nishikawa, Y Kubo, H Kido, T Nakayama, N Nakamura

Research Division, The Green Cross Corporation, Osaka, Japan. ac43451@yoshitomi.co.jp

General pharmacology 1999 Mar

filter terms:

We investigated the protective effect of chronic treatment with AE0047, a dihydropyridine-type calcium channel blocker, on vascular endothelial abnormalities in stroke-prone spontaneously hypertensive rats (SHRSP). Ten-week repeated antihypertensive treatment with AE0047 inhibited blood pressure elevation and improved endothelium-dependent relaxation in response to acetylcholine in aorta isolated from SHRSP. Furthermore, the abnormal production of prostaglandin I2 and thromboxane A2 in the aorta was normalized to a level equivalent to that in Wistar-Kyoto rats. These results suggest that chronic treatment with AE0047 exerts protective effects against endothelial abnormalities associated with the development of hypertension.

Citation

M Nishikawa, Y Kubo, H Kido, T Nakayama, N Nakamura. Protection against endothelial abnormalities by a novel calcium channel blocker, AE0047, in stroke-prone spontaneously hypertensive rats. General pharmacology. 1999 Mar;32(3):299-305