Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase.
J Lee, S U Kang, M K Kang, M W Chun, Y J Jo, J H Kwak, S Kim
Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Korea.
Bioorganic & medicinal chemistry letters 1999 May 17Four stable analogues of methionyl adenylate (3-6) were designed as inhibitors of methionyl-tRNA synthetase and synthesized from 2',3'-isopropylideneadenosine. They strongly inhibited aminoacylation activity of methionyl-tRNA synthetases isolated from Escherichia coli, Mycobacterium tuberculosis, Saccharomyces cerevisiae and human. Among the microorganisms tested, however, these chemicals showed the growth inhibition effect only on E. coli.
Citation
J Lee, S U Kang, M K Kang, M W Chun, Y J Jo, J H Kwak, S Kim. Methionyl adenylate analogues as inhibitors of methionyl-tRNA synthetase. Bioorganic & medicinal chemistry letters. 1999 May 17;9(10):1365-70
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PMID: 10360737
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