Nuclear transport: randy couples.

I G Macara

Department of Pharmacology, Center for Cell Signaling, University of Virginia, 7196 Hospital West, 577, Health Sciences Center, Charlottesville, Virginia 22908, USA. imacara@virginia.edu

Current biology : CB 1999 Jun 17

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The recently solved structures of the Ran GTPase with a Ran-binding domain and with karyopherin-beta2 have revealed unusually tight embraces that provide important insights into the mechanism of nuclear transport and the many ways in which common protein folds are adapted to perform very different functions.