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Protein kinase C has recently been shown to modulate the slow recovery from inactivation of Na+ channels in apical dendrites of hippocampal CA1 pyramidal neurons. Moreover, dendritic, A-type K+ channels have been found to be modulated by protein kinases A and C and by mitogen-activated protein kinase. The electrical signalling ability of these dendrites is thus highly regulated by a number of neurotransmitters and second-messenger systems.

Citation

D Johnston, D A Hoffman, C M Colbert, J C Magee. Regulation of back-propagating action potentials in hippocampal neurons. Current opinion in neurobiology. 1999 Jun;9(3):288-92

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PMID: 10395568

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