Synthesis and preliminary pharmacological evaluation of thiophene analogues of viloxazine as potential antidepressant drugs.

C Corral, J Lissavetzky, I Manzanares, V Darias, M A Expósito-Orta, J A Martïn Conde, C C Sánchez-Mateo

Instituto de Química Médica (CSIC), Madrid, Spain.

Bioorganic & medicinal chemistry 1999 Jul

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A series of eight thienyloxymethylmorpholines, thiophene analogues of viloxazine, have been synthesized by three different routes. The preliminary pharmacological evaluation of this series shows antidepressant properties on the mice models used with a light sedative action. The structure-activity relationship is established in a first approximation.

Citation

C Corral, J Lissavetzky, I Manzanares, V Darias, M A Expósito-Orta, J A Martïn Conde, C C Sánchez-Mateo. Synthesis and preliminary pharmacological evaluation of thiophene analogues of viloxazine as potential antidepressant drugs. Bioorganic & medicinal chemistry. 1999 Jul;7(7):1349-59