Probing the extended binding determinants of oligosaccharyl transferase with synthetic inhibitors of asparagine-linked glycosylation.

M de L Ufret, B Imperiali

Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA.

Bioorganic & medicinal chemistry letters 2000 Feb 7

filter terms:

Protein glycosylation is associated with many critical biological processes. In connection with studies on the mechanism of asparagine-linked glycosylation by the enzyme oligosaccharyl transferase, we have prepared peptide inhibitors that interact with the enzyme at nanomolar concentrations. Herein we describe efforts directed toward improving the binding properties of these inhibitors.

Citation

M de L Ufret, B Imperiali. Probing the extended binding determinants of oligosaccharyl transferase with synthetic inhibitors of asparagine-linked glycosylation. Bioorganic & medicinal chemistry letters. 2000 Feb 7;10(3):281-4