An analysis of 3H-tamoxifen binding with the cell plasma membranes of the rat uterus].

E N Kareva, E V Solov'eva, N V Kirpichnikova, A V Tumanov, N Iu Rybalko

Molecular Pharmacology and Radiobiology Chair, State Medical University, Moscow, Russia.

Eksperimental'naia i klinicheskaia farmakologiia 2000 Mar-Apr

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The effect of phencarol, ranitidine, propranolol, atropine, and diethylstilbestrol (known as modulators of the tamoxifen-binding sites in plasma membranes) on the 3H-tamoxifen binding to the plasma membrane fraction of white rat uterine cells was studied by determining the amounts of estradiol and H1- and H2-receptors. The interaction of tamoxifen with various receptors of uterine cells may be significant for evaluation of the tumor activity of this compound.

Citation

E N Kareva, E V Solov'eva, N V Kirpichnikova, A V Tumanov, N Iu Rybalko. An analysis of 3H-tamoxifen binding with the cell plasma membranes of the rat uterus]. Eksperimental'naia i klinicheskaia farmakologiia. 2000 Mar-Apr;63(2):51-3