J Okuda, M Otsuki, T Oh, T Nishino
Department of Microbiology, Kyoto Pharmaceutical University, Yamashina-ku, Japan. okudao2e@daiichipharm.co.jp
The Journal of antimicrobial chemotherapy 2000 JulWe compared the in vitro antibacterial activity of DU-6681a against Gram-positive and Gram-negative bacteria with that of R-95867, faropenem and oral cephalosporins such as cefcapene, cefotiam and cefpodoxime. DU-6681a is an active form of the new oral carbapenem compound DZ-2640, which is an ester-type prodrug, and R-95867 is an active form of the oral carbapenem CS-834. Against most Gram-positive bacteria, DU-6681a was as active as or two- to 16-fold more potent than R-95867 and faropenem in terms of MIC(90), and comparable to or two- to 64-fold more effective than the cephalosporins. Against most Gram-negative bacteria, the activity of DU-6681a was the same as or two- to 16-fold more potent than that of R-95867, and comparable to or two- to 2048-fold higher than that of faropenem and the cephalosporins.
J Okuda, M Otsuki, T Oh, T Nishino. In vitro activity of DU-6681a, an active form of the new oral carbapenem compound DZ-2640, in comparison with that of R-95867, faropenem and oral cephalosporins. The Journal of antimicrobial chemotherapy. 2000 Jul;46(1):101-8
PMID: 10882697
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