Correlation Engine 2.0
Clear Search sequence regions

The experiments with dogs exposed to 100 Gy of accelerated electrons demonstrated a significant role of prostaglandins in the origin of early post-radiation dyspepsia. Their significance for genesis of post-radiation dyspeptic disturbance caused by exposure to superhigh doses becomes clear-cut when a combination of an antiemetic and inhibitors of prostaglandin biosynthesis is used. A study of the effect of dexamethasone, a blocker of arachidonic acid release, and of voltaren, an inhibitor of prostaglandin formation from cyclic endoperoxide, suggests that it would be appropriate to prevent radiation vomiting and diarrhea by inhibiting both of the above stages in prostaglandin biosynthesis.


K S Martirosov, Iu G Grigor'ev, V V Zorin, P N Iashkin. An experimental study of the role of prostaglandins in the mechanism of the occurrence of dyspeptic disorders during the primary reaction after body exposure to ionizing radiation at large doses]. Radiatsionnaia biologiia, radioecologiia / Rossiń≠skaia akademiia nauk. 2000 May-Jun;40(3):272-6

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 10907403

View Full Text