An experimental study of the role of a blockade of serotonin 5-HT3 receptors and dopamine D2 receptors in the mechanism of the occurrence of early radiation vomiting in monkeys].

K S Martirosov, Iu G Grigor'ev, V V Zorin, I E Andrianova

State Research Center of Russia, Institute of Biophysics, Moscow. ibkoguc@alara.msk.su

Radiatsionnaia biologiia, radioecologiia / Rossiĭskaia akademiia nauk 2000 May-Jun

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The experiments with M. fasciculata monkeys exposed to 137Cs gamma-radiation with a dose of 6.9 Gy showed that Latranum, a blocker of serotonin 5-HT3 receptors, is a more efficient antiemetic than Dimetphramidum, a D2 dophamin lytic. This is suggested by fewer animals with emetic reaction of by less severe vomiting in case they have any. The results agree well with a hypothesis that serotonin receptors are dominant in the chemoreceptor trigger zone of monkeys.

Citation

K S Martirosov, Iu G Grigor'ev, V V Zorin, I E Andrianova. An experimental study of the role of a blockade of serotonin 5-HT3 receptors and dopamine D2 receptors in the mechanism of the occurrence of early radiation vomiting in monkeys]. Radiatsionnaia biologiia, radioecologiia / Rossiĭskaia akademiia nauk. 2000 May-Jun;40(3):277-80