Molecular mechanisms of invasion by cancer cells, leukocytes and microorganisms.

T Lauwaet, M J Oliveira, M Mareel, A Leroy

Laboratory of Experimental Cancerology, Department of Radiotherapy and Nuclear Medicine, Ghent University Hospital, Belgium.

Microbes and infection / Institut Pasteur 2000 Jul

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Invasion is a phenotype common to cancer cells, leukocytes, parasites, bacteria and viruses, involving cell-cell adhesion, cell-matrix adhesion, proteolysis and motility. These activities are regulated by the cross talk between invaders and host. We discuss the invasion-related molecular interactions of E-cadherin, integrins, matrix metalloproteinases and the chemokine receptor RANTES.

Citation

T Lauwaet, M J Oliveira, M Mareel, A Leroy. Molecular mechanisms of invasion by cancer cells, leukocytes and microorganisms. Microbes and infection / Institut Pasteur. 2000 Jul;2(8):923-31