Clinical rubella reinfection during pregnancy in a previously vaccinated woman.

Y Aboudy, B Barnea, L Yosef, T Frank, E Mendelson

Central Virology Laboratory, Public Health Services, Ministry of Health and The Chaim Sheba Medical Center, Tel-Hashomer, 52621, Israel.

The Journal of infection 2000 Sep

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We report a documented case of clinically apparent rubella reinfection during pregnancy with rubelliform rash and fever followed by lymphodenopathy at the 18th week of gestation, in a previously vaccinated woman with haemagglutination inhibition (HI) antibody titre of 1:32. The serological tests results (including neutralizing antibodies) demonstrated a significant rise in her rubella specific IgG level with strongly positive IgM reactivity. In addition, rubella-specific IgG antibody avidity testing displayed high avidity index (53-88%) typical of rubella reinfection. Umbilical cord blood, drawn by sonographic-guided cordocentesis at 24 weeks' gestation, was found to be negative for rubella-specific IgM antibody. The pregnancy was continued to term, and a healthy infant was born. Copyright 2000 The British Infection Society.

Citation

Y Aboudy, B Barnea, L Yosef, T Frank, E Mendelson. Clinical rubella reinfection during pregnancy in a previously vaccinated woman. The Journal of infection. 2000 Sep;41(2):187-9