M L Mangoni, N Grovale, A Giorgi, G Mignogna, M Simmaco, D Barra
Dipartimento di Scienze Biomediche, Università 'G. d'Annunzio', 66100, Chieti, Italy.
Peptides 2000 NovSkin secretions of amphibia of the Bombina genus contain two families of antimicrobial peptides, the bombinins (bombinin-like peptides) and the bombinins H (H for hydrophobic and hemolytic). The latter family includes a number of peptides containing a D-amino acid in the second position, in addition to their corresponding all L-isomers. The antimicrobial activity of three pairs of bombinin H isomers, H2/H4, H6/H7 and GH-1D/GH-1L, has been investigated. The first two pairs of peptides were actually isolated from the secretion, whereas the third was synthesized according to the sequence deduced from a gene coding for a bombinin-like peptide in Bombina orientalis.
M L Mangoni, N Grovale, A Giorgi, G Mignogna, M Simmaco, D Barra. Structure-function relationships in bombinins H, antimicrobial peptides from Bombina skin secretions. Peptides. 2000 Nov;21(11):1673-9
PMID: 11090921
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