New long-wavelength perylenequinones: synthesis and phototoxicity of hypocrellin B derivatives.

L Li, Y Chen, J Shen, M Zhang, T Shen

Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing, PR China.

Biochimica et biophysica acta 2000 Sep 1

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Five new derivatives of hypocrellin B were obtained from the reactions of hypocrellin B with ammonia and ethanolamine. Their photophysical and photochemical properties were investigated. The phototoxicity of one compound on AH cells irradiated with red light (lambda = 600-700 nm) was also studied. Their significantly enhanced red absorptivities at wavelengths longer than 600 nm and singlet oxygen-generating function qualify them as promising photodynamic therapy agents.

Citation

L Li, Y Chen, J Shen, M Zhang, T Shen. New long-wavelength perylenequinones: synthesis and phototoxicity of hypocrellin B derivatives. Biochimica et biophysica acta. 2000 Sep 1;1523(1):6-12