Domain architecture of a Caenorhabditis elegans AKAP suggests a novel AKAP function.

S Herrgård, P Jambeck, S S Taylor, S Subramaniam

Department of Bioengineering, University of California, San Diego, CA 92093, USA.

FEBS letters 2000 Dec 8

filter terms:

A-kinase anchoring proteins (AKAPs) are adapter proteins that are involved in directing cAMP-dependent protein kinase and some other signaling enzymes to certain intracellular locations. In this study, we investigate the domain architecture of an AKAP from Caenorhabditis elegans (AKAP(CE)). We show that AKAP(CE) shares two domains with the Smad anchor for receptor activation, a FYVE-finger and a transforming growth factor beta (TGFbeta) receptor binding domain, suggesting that AKAP(CE) may interact with a receptor belonging to the TGFbeta receptor family. This predicted novel AKAP function supports the recent view of AKAPs as adapter proteins that can be involved in various signaling pathways.

Citation

S Herrgård, P Jambeck, S S Taylor, S Subramaniam. Domain architecture of a Caenorhabditis elegans AKAP suggests a novel AKAP function. FEBS letters. 2000 Dec 8;486(2):107-11