M R Landauer, C A Castro, K A Benson, J B Hogan, J F Weiss
Armed Forces Radiobiology Research Institute, Radiation Casualty Management Team, 8901 Wisconsin Avenue, Bethesda, MD 20889-5603, USA. landauer@mx.afrri.usuhs.mil
Journal of applied toxicology : JAT 2001 Jan-FebThe effect of combining a radiation-protective phosphorothioate with another agent was investigated in an attempt to increase radioprotection and reduce toxicity. The calcium channel blocker nimodipine (NIMO) was administered alone (1 or 10 mg kg-1) or in combination with 200 mg kg-1 of the phosphorothioate radioprotector WR-151327 (WR) (S-3-(3-methylaminopropylamino)propylphosphorothioic acid). Radioprotection as measured (30-day survival) of mice treated i.p. 30 min before (60)Co irradiation at a dose rate of 1 Gy min-1 was evaluated in CD2F1 male mice. The effects of nimodipine and WR-151327 on locomotor activity were investigated also in a separate group of non-irradiated mice. The LD(50/30) for the Emulphor vehicle control group was 8.56. For nimodipine alone (1 or 10 mg kg-1) the LD(50/30)was 8.39 and 10.21 Gy, respectively, yielding dose modification factors (DMFs) of 0.98 and 1.19, respectively. When WR-151327 was given alone, the
M R Landauer, C A Castro, K A Benson, J B Hogan, J F Weiss. Radioprotective and locomotor responses of mice treated with nimodipine alone and in combination with WR-151327. Journal of applied toxicology : JAT. 2001 Jan-Feb;21(1):25-31
PMID: 11180277
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