Department of Mathematics and Science Education, Graduate School of Science, Science University of Tokyo, Japan.
Bioscience, biotechnology, and biochemistry 2001 MarGibbilimbols A [(E)-4-(4-decenyl)phenol, 1], B [(E)-4-(3-decenyl)phenol, 2], C [(E)-4-(4-octenyl)phenol, 3] and D [(E)-4-(3-octenyl)phenol, 4] were synthesized by coupling the phenolic parts with the alkyne parts and then reducing the triple bond of the resulting alkynylphenols. These alkenylphenols (1-4) are the cytotoxic and antibacterial constituents of the leaves of a medicinal plant (Piper gibbilimbum) that is used as a traditional medicine in Papua New Guinea.
Y Abe, H Takikawa, K Mori. Synthesis of gibbilimbols A-D, cytotoxic and antibacterial alkenylphenols isolated from Piper gibbilimbum. Bioscience, biotechnology, and biochemistry. 2001 Mar;65(3):732-5
PMID: 11330702
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