Studies on the hepatocyte protective activity and the structure-activity relationships of quinic acid and caffeic acid derivatives from the flower buds of Lonicera bournei.

T Xiang, Q B Xiong, A I Ketut, Y Tezuka, T Nagaoka, L J Wu, S Kadota

Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.

Planta medica 2001 Jun

filter terms:

13 quinic acid derivatives along with caffeic acid, methyl caffeate, myo-inositol, bis[5-formylfurfuryl] ether and 6,7-dihydroxycoumarin were isolated from the ethanol extract of the flower buds of Lonicera bournei Hemsl., among which 8 compounds were firstly obtained from this genus. The effects of different solvent soluble fractions of the ethanol extract and the pure compounds on heptocyte death induced by D-galactosamine (D-GalN)/tumor necrosis factor alpha (TNF-alpha) were studied, and the structure-activity relationships were also discussed.

Citation

T Xiang, Q B Xiong, A I Ketut, Y Tezuka, T Nagaoka, L J Wu, S Kadota. Studies on the hepatocyte protective activity and the structure-activity relationships of quinic acid and caffeic acid derivatives from the flower buds of Lonicera bournei. Planta medica. 2001 Jun;67(4):322-5