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Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4.
S Jäger, J Strayle, W Heinemeyer, D H Wolf
The EMBO journal 2001 Aug 15
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In eukaryotes, the ubiquitin-proteasome system plays a major role in selective protein breakdown for cellular regulation. Here we report the discovery of a new essential component of this degradation machinery. We found the Saccharomyces cerevisiae protein Cic1 attached to 26S proteasomes playing a crucial role in substrate specificity for proteasomal destruction. Whereas degradation of short-lived test proteins is not affected, cic1 mutants stabilize the F-box proteins Cdc4 and Grr1, substrate recognition subunits of the SCF complex. Cic1 interacts in vitro and in vivo with Cdc4, suggesting a function as a new kind of substrate recruiting factor or adaptor associated with the proteasome.
Citation
S Jäger, J Strayle, W Heinemeyer, D H Wolf.
Cic1, an adaptor protein specifically linking the 26S proteasome to its substrate, the SCF component Cdc4.
The EMBO journal.
2001 Aug 15;20(16):4423-31
Mesh Tags
Amino Acid Sequence
Carrier Proteins
Cell Cycle Proteins
F-Box Proteins
F-Box-WD Repeat-Containing Protein 7
Fungal Proteins
Humans
Molecular Sequence Data
Peptide Hydrolases
Peptide Synthases
Proteasome Endopeptidase Complex
SKP Cullin F-Box Protein Ligases
Saccharomyces cerevisiae Proteins
Substrate Specificity
Ubiquitin-Protein Ligases
Ubiquitins
Substances
Carrier Proteins
Cell Cycle Proteins
Cic1 protein, S cerevisiae
F-Box Proteins
F-Box-WD Repeat-Containing Protein 7
FBXW7 protein, human
Fungal Proteins
Saccharomyces cerevisiae Proteins
Ubiquitins
GRR1 protein, S cerevisiae
SKP Cullin F-Box Protein Ligases
Ubiquitin-Protein Ligases
Peptide Hydrolases
Proteasome Endopeptidase Complex
ATP dependent 26S protease
Peptide Synthases
PMID: 11500370
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