A simple procedure for synthesis of roxindole, a dopamine D2-receptor agonist.

F Csende

Taxus Pharmaceuticals, H-4440 Tiszavasvári, Vasvári P. u. 61., Hungary. csende@elender.hu

Archiv der Pharmazie 2001 Jul

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A modified convenient and high yielding synthetic route for the preparation of the dopamine agonist roxindole 1 is described. The key step in our method is the phase-transfer catalyzed reaction of gamma-butyrolactone with 5-methoxyindole which results in the indolylbutyric acid derivative directly in one step.