The effects of ozone and toxic air particles on airway function in mice].

P.L. Shupik Medical Academy for Postgraduate Training, Kiev.

Fiziolohichnyĭ zhurnal (Kiev, Ukraine : 1994) 2001

We tested the hypothesis that exposures to particulate matter and ozone can produce asthma-like symptoms. Balb/c mice received a single intratracheal instillation of particulate matter and TiO2 or they were exposed to low concentration of ozone. We have established that exposure to particulate matter produces increased responsiveness to methacholine in mice. Exposure to ozone and TiO2 did not produce changes in respiratory mechanics. These data are spreading our understanding about mechanisms of environmental influence on airways.