Identification of a novel protease inhibitor gene that is highly expressed in the prostate.

Department of Laboratory Medicine, Lund University, University Hospital MAS, S-205 02 Malmö, Sweden. Ake.Lundwall@klkemi.mas.lu.se

Biochemical and biophysical research communications 2002 Jan 11

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A novel gene was identified 52 kb upstream of the gene encoding the protease inhibitor elafin (PI3) on human chromosome 20q12-13.1. The transcript of the new gene, denoted huWAP2, was characterized by rapid amplification of cDNA ends and DNA sequencing. The size is 774 bp and it gives rise to a polypeptide of 111 amino acid residues that is homologous to elafin and similar WAP-type protease inhibitors. By RT-PCR it was shown that the gene is highly expressed in prostate, skin, lung, and esophagus. (c)2002 Elsevier Science.

Citation

Ake Lundwall, Adam Clauss. Identification of a novel protease inhibitor gene that is highly expressed in the prostate. Biochemical and biophysical research communications. 2002 Jan 11;290(1):452-6