Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats.

Nathan L Lubbers, James S Polakowski, Craig D Wegner, Sandra E Burke, Gilbert J Diaz, Katina M Daniell, Bryan F Cox

Department of Integrative Pharmacology, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064-6119, USA. nathan.lubbers@abbott.com

European journal of pharmacology 2002 Jan 18

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Bimoclomol has been shown to increase an inducible member of the heat shock protein 70 family (HSP70) and cytoprotect in vitro. Here, we addressed whether oral pretreatment of rats with bimoclomol could elevate myocardial HSP70 and reduce infarct size in a rat model of ischemia and reperfusion. Rats were pretreated with bimoclomol at 3, 6 or 18 h or with 42 degrees thermal stress 24 h before ischemia. Infarct size was significantly decreased 6 h after oral administration of bimoclomol and 24 h after thermal stress. Left ventricles from a separate group of rats were examined for HSP70 levels. Western blots showed a significant increase in HSP70 6 h after oral administration of bimoclomol and 24 h after thermal stress. There was a significant correlation (P<0.05) between HSP70 induction and infarct size reduction, whether produced by thermal stress or oral administration of bimoclomol. Thus, bimoclomol can increase HSP70 and reduce infarct size in a rat model of ischemia and reperfusion.

Citation

Nathan L Lubbers, James S Polakowski, Craig D Wegner, Sandra E Burke, Gilbert J Diaz, Katina M Daniell, Bryan F Cox. Oral bimoclomol elevates heat shock protein 70 and reduces myocardial infarct size in rats. European journal of pharmacology. 2002 Jan 18;435(1):79-83