Isolation and structure determination of obyanamide, a novel cytotoxic cyclic depsipeptide from the marine cyanobacterium Lyngbya confervoides.

Philip G Williams, Wesley Y Yoshida, Richard E Moore, Valerie J Paul

Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, USA.

Journal of natural products 2002 Jan

filter terms:

Obyanamide (1) was isolated from a variety of the marine cyanobacterium Lyngbya confervoides collected in Saipan, Commonwealth of the Northern Mariana Islands. Gross structure elucidation of this novel cyclic depsipeptide relied on extensive application of 2D NMR techniques. The absolute stereochemistry was deduced by chiral chromatography of the hydrolysis products and comparison with authentic and synthetic standards. Obyanamide (1) was cytotoxic against KB cells with an IC(50) of 0.58 microg/mL.

Citation

Philip G Williams, Wesley Y Yoshida, Richard E Moore, Valerie J Paul. Isolation and structure determination of obyanamide, a novel cytotoxic cyclic depsipeptide from the marine cyanobacterium Lyngbya confervoides. Journal of natural products. 2002 Jan;65(1):29-31