Alpha-glucosidase inhibitory constituents from Cuscuta reflexa.

Erum Anis, Itrat Anis, Saeed Ahmed, Ghulam Mustafa, Abdul Malik, Nighat Afza, Syed Muhammad Abdul Hai, Syed Shahzad-ul-hussan, Muhammad Iqbal Choudhary

International Center for Chemical Sciences, H.E.J Research Institute of Chemistry, University of Karachi, Pakistan.

Chemical & pharmaceutical bulletin 2002 Jan

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Two new compounds, 7'-(3',4'-dihydroxyphenyl)-N-[(4-methoxyphenyl)ethyl]propenamide (4), and 7'-(4'-hydroxy,3'-methoxyphenyl)-N-[(4-butylphenyl)ethyl]propenamide (5) have been isolated from Cuscuta reflexa along with five known compounds, 6,7-dimethoxy-2H-1-benzopyran-2-one (1), 3-(3,4-dihydroxyphenyl)-2-propen-1-ethanoate (2), 6,7,8-trimethoxy-2H-1-benzopyran-2-one (3), 3-(4-O-beta-D-glucopyranoside-3,5-dimethoxyphenyl)-2-propen-1-ol (6), 2-(3-hydroxy-4-methoxyphenyl)-3,5-dihydroxy-7-O-beta-D-glucopyranoside-4H-1-benzopyrane-4-one (7), reported for the first time from this species. Structures of these compounds were determined by spectral analysis. These compounds showed strong inhibitory activity against alpha-glucosidase.

Citation

Erum Anis, Itrat Anis, Saeed Ahmed, Ghulam Mustafa, Abdul Malik, Nighat Afza, Syed Muhammad Abdul Hai, Syed Shahzad-ul-hussan, Muhammad Iqbal Choudhary. Alpha-glucosidase inhibitory constituents from Cuscuta reflexa. Chemical & pharmaceutical bulletin. 2002 Jan;50(1):112-4