Experimental study of the role of blocking 5-HT3-receptors of serotonin and D2-receptors of dopamine in the mechanism of early radiation vomiting in dogs].

K S Martirosov, Iu G Grigor'ev, M V Borovkov, V V Zorin

State Research Center of Russia-Institute of Biophysics, Moscow, 123182 Russia.

Radiatsionnaia biologiia, radioecologiia / Rossiĭskaia akademiia nauk 2002 Jan-Feb

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The experiments on dogs exposed to 137Cs gamma quanta at doses of 8 and 20 Gy showed that Latranum, a selective blocker of serotonin 5-HT3-receptors, is a more efficient antiemetic than Dimetpramidum, a D2-dophamin lytic. This is suggested by fewer animals with emetic reaction or by less severe vomiting in case they have any. The results, taking account of earlier data obtained in the experiments on M. fascicularis monkeys, show that the antiemetic effect of the blocker of serotonin 5-HT3-receptors Latranum is not species-specific and equally well manifests itself in animals with different constitutions of the chemoreceptor trigger zone.

Citation

K S Martirosov, Iu G Grigor'ev, M V Borovkov, V V Zorin. Experimental study of the role of blocking 5-HT3-receptors of serotonin and D2-receptors of dopamine in the mechanism of early radiation vomiting in dogs]. Radiatsionnaia biologiia, radioecologiia / Rossiĭskaia akademiia nauk. 2002 Jan-Feb;42(1):75-9