Anti-lipid-peroxidative principles from Tournefortia sarmentosa.

Yun-Lian Lin, Ying-Ying Chang, Yueh-Hsiung Kuo, Ming-Shi Shiao

National Research Institute of Chinese Medicine, Taipei 112, Taiwan. yllin@cma23.nricm.edu.tw

Journal of natural products 2002 May

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Using the inhibition of Cu(2+)-induced low-density-lipoprotein (LDL) peroxidation to direct fractionation, four new benzenoids, tournefolal (1), tournefolic acids A (2) and B (3), and B ethyl ester (4), together with salvianolic acid A (5), isosalvianolic acid C (6), lithospermic acid (7), salvianolic acid F (8), and rosmarinic acid (9), were isolated from the stems of Tournefortia sarmentosa. The structures of the new compounds 1-4 were elucidated on the basis of spectral and chemical methods. Furthermore, the anti-LDL-peroxidative activity of the isolated compounds was determined. All isolated compounds exhibited more potent activity than probucol except for salvianolic acid F (8).

Citation

Yun-Lian Lin, Ying-Ying Chang, Yueh-Hsiung Kuo, Ming-Shi Shiao. Anti-lipid-peroxidative principles from Tournefortia sarmentosa. Journal of natural products. 2002 May;65(5):745-7