Neosordarin and hydroxysordarin, two new antifungal agents from Sordaria araneosa.

Paolo Davoli, Günther Engel, Andreas Werle, Olov Sterner, Timm Anke

Lehrbereich Biotechnologie der Universität, Kaiserslautern, Germany.

The Journal of antibiotics 2002 Apr

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Two novel antifungal agents belonging to the sordarin family have been isolated from fermentations of Sordaria araneosa by bioassay-guided purification and their structures elucidated by NMR techniques. Neosordarin (1) is closely related to the recently discovered hypoxysordarin (2), with only small differences on the aliphatic side chain acylating the hydroxyl in the 3'-position of the sordarose moiety. Hydroxysordarin (3) closely resembles sordarin (4), the only slight difference being the replacement of sordarose with altrose as the sugar unit.

Citation

Paolo Davoli, Günther Engel, Andreas Werle, Olov Sterner, Timm Anke. Neosordarin and hydroxysordarin, two new antifungal agents from Sordaria araneosa. The Journal of antibiotics. 2002 Apr;55(4):377-82