Jamie Fitzgerald, Su Tay Ting, John F Bateman
Cell and Matrix Biology Research Unit, Murdoch Childrens Research Institute and Department of Paediatrics, University of Melbourne, Royal Children's Hospital, Parkville, Vic., Australia. fitzgerj@cryptic.rch.unimelb.edu.au
FEBS letters 2002 Apr 24We report a new member of the von Willebrand factor A-domain protein superfamily, WARP (for von Willebrand factor A-domain-related protein). The full-length mouse WARP cDNA is 2.3 kb in size and predicts a protein of 415 amino acids which contains a signal sequence, a VA-like domain, two fibronectin type III-like repeats, and a short proline- and arginine-rich segment. WARP mRNA was expressed predominantly in chondrocytes and in vitro expression experiments in transfected 293 cells indicated that WARP is a secreted glycoprotein that forms disulphide-bonded oligomers. We conclude that WARP is a new member of the von Willebrand factor A-domain (VA-domain) superfamily of extracellular matrix proteins which may play a role in cartilage structure and function.
Jamie Fitzgerald, Su Tay Ting, John F Bateman. WARP is a new member of the von Willebrand factor A-domain superfamily of extracellular matrix proteins. FEBS letters. 2002 Apr 24;517(1-3):61-6
PMID: 12062410
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