Non-canonical Wnt signalling and regulation of gastrulation movements.
Masazumi Tada, Miguel L Concha, Carl Philipp Heisenberg
Department of Anatomy and Developmental Biology, University College London, Gower Street, London WC1E 6BT, UK. m.tada@ucl.ac.uk
Seminars in cell & developmental biology 2002 JunMembers of the Wnt family have been implicated in a variety of developmental processes including axis formation, patterning of the central nervous system and tissue morphogenesis. Recent studies have shown that a Wnt signalling pathway similar to that involved in the establishment of planar cell polarity in Drosophila regulates convergent extension movements during zebrafish and Xenopus gastrulation. This finding provides a good starting point to dissect the complex cell biology and genetic regulation of vertebrate gastrulation movements.
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Masazumi Tada, Miguel L Concha, Carl Philipp Heisenberg. Non-canonical Wnt signalling and regulation of gastrulation movements. Seminars in cell & developmental biology. 2002 Jun;13(3):251-60
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PMID: 12137734
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