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Synthesis of ceramidated GLA-60 derivatives.
Tsuyoshi Nakamura, Masao Shiozaki, Shin-ichi Kurakata
Exploratory Chemistry Research Laboratories, Sankyo Co., Ltd., Hiromachi 1-2-58, Shinagawa-ku, Tokyo 140-8710, Japan.
Carbohydrate research 2002 Sep 3Sizes of these terms reflect their relevance to your search.
Ceramidated GLA-60 derivatives 11 and 11' were synthesized from 1 via glycosidation of ceramide derivative 12 as a glycosyl acceptor with GLA-60 derivative 5 as a glycosyl donor, and successive conversion. Compound 11' showed only weak LPS-antagonistic activity without showing any LPS-agonistic activity.
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Tsuyoshi Nakamura, Masao Shiozaki, Shin-ichi Kurakata. Synthesis of ceramidated GLA-60 derivatives. Carbohydrate research. 2002 Sep 3;337(15):1343-9
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PMID: 12204617
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